Important Safety Information for Compounded Semaglutide

Semaglutide is a synthetic glucagon-like peptide-1 receptor agonist (GLP-1RA). Once it is released into the bloodstream via the gut, it improves glycemic control with diet and exercise in adults with Type2 diabetes. It is also indicated for weight loss management along with diet and exercise regimen. It binds and activates the GLP-1 receptor. GLP-1 is a regulator of glucose homeostasis and is released after ingestion of carbohydrates or fats. GLP-1 enhances insulin secretion from pancreatic beta cells when there is an elevation of glucose. It also suppresses glucagon secretion, decreases gastric emptying which decreases appetite and decreases A1c. It can be given in combination with Cyanocobalamin (Vitamin B12) or Pyridoxine (Vitamin B6).

Some of the adverse reactions or side effects may include diarrhea, nausea, vomiting, abdominal pain decreased appetite, indigestion, bloating, gastroesophageal reflex disease (GERD), dizziness, or constipation. Anaphylaxis, skin rash, sinus tachycardia, and hypoglycemia have also been reported. Do not use if hypersensitive to Semaglutide or with other inactive ingredients.

Semaglutide is given subcutaneously once weekly. Doses are individually based per patient. It is to be stored in the refrigerator and keep away from heat or light or moisture. Do not use past the expiration date or BUD. Keep out of reach of children. Dispose of any unused after the beyond use date. Do not flush down the sink or drain.

Reporting Side Effects

Report any negative side effects of semaglutide to FDA MedWatch at 1-800-FDA-1088 or visit www.fda.gov/medwatch.